Abril‐Coello, Rebeca, Marta Correyero‐León, Luis Ceballos‐Laita, and Sandra Jiménez‐Barrio. “Benefits of Physical Therapy in Improving Quality of Life and Pain Associated with Endometriosis: A Systematic Review and Meta‐analysis.” International Journal of Gynecology & Obstetrics 162, no. 1 (July 2023): 233–43. https://doi.org/10.1002/ijgo.14645
I wish I had full access to this because there are remarks in Results and Conclusion that seriously look like they need to be examined more closely.
Brown, Julie, Tineke J Crawford, Claire Allen, Sally Hopewell, and Andrew Prentice. “Nonsteroidal Anti-Inflammatory Drugs for Pain in Women with Endometriosis.” Edited by Cochrane Gynaecology and Fertility Group. Cochrane Database of Systematic Reviews 2017, no. 5 (January 23, 2017). https://doi.org/10.1002/14651858.CD004753.pub4
There’s much in this paper that I find shocking. The fact that NSAIDs have not been demonstrated to be better than placebo in RCT for endometriosis-related pain is bonkers. The fact that there have only been two tiny, relatively incomplete trials investigating this question since 2009 is just awful.
Bulun, Serdar E, Bahar D Yilmaz, Christia Sison, Kaoru Miyazaki, Lia Bernardi, Shimeng Liu, Amanda Kohlmeier, Ping Yin, Magdy Milad, and JianJun Wei. “Endometriosis.” Endocrine Reviews 40, no. 4 (August 1, 2019): 1048–79. https://doi.org/10.1210/er.2018-00242.
Cacciottola, Luciana, Jacques Donnez, and Marie-Madeleine Dolmans. “Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets?” International Journal of Molecular Sciences 22, no. 13 (July 1, 2021): 7138. https://doi.org/10.3390/ijms22137138.
Carmona, F. “Therapeutic Role of Dance in the Treatment of Endometriosis-Related Chronic Pelvic Pain: A Proof-of-Concept Study.” World Journal of Gynecology & Womens Health 1, no. 2 (October 12, 2018). https://doi.org/10.33552/WJGWH.2018.01.000507.
Collinet, P., X. Fritel, C. Revel-Delhom, M. Ballester, P.A. Bolze, B. Borghese, N. Bornsztein, et al. “Prise en charge de l’endométriose : recommandations pour la pratique clinique CNGOF-HAS (texte court).” Gynécologie Obstétrique Fertilité & Sénologie 46, no. 3 (March 2018): 144–55. https://doi.org/10.1016/j.gofs.2018.02.027.
Donnez, Jacques, and Luciana Cacciottola. “Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options.” International Journal of Molecular Sciences 23, no. 3 (January 28, 2022): 1518. https://doi.org/10.3390/ijms23031518
This document highlights the importance of looking at oxidative stress factors and the need for treatments that target both inflammatory and hormonal pathways that actually reduce or inhibit endometriosis from developping. Mention of microbiata is also really interesting, gut biome is a real craze these days.
Gourbail, Laëtitia. “Prise en charge de l’endométriose: méthode Recommandations pour la pratique clinique.” Haute autorité de santé, Décembre 2017. https://doi.org/10.1016/j.gofs.2018.02.027.
Guidone, Heather C. “The Womb Wanders Not: Enhancing Endometriosis Education in a Culture of Menstrual Misinformation.” In The Palgrave Handbook of Critical Menstruation Studies, edited by Chris Bobel, Inga T. Winkler, Breanne Fahs, Katie Ann Hasson, Elizabeth Arveda Kissling, and Tomi-Ann Roberts, 269–86. Singapore: Springer Singapore, 2020. https://doi.org/10.1007/978-981-15-0614-7_22.
Honda, Michiko, Wataru Isono, Akira Tsuchiya, Ako Saito, Hiroko Tsuchiya, Reiko Matsuyama, Akihisa Fujimoto, and Osamu Nishii. “Significant Risk Factors for Malignant Transformation of Ovarian Endometrioma during Dienogest Treatment: A Case Report and Retrospective Study.” Journal of Medical Case Reports 13, no. 1 (December 2019): 314. https://doi.org/10.1186/s13256-019-2236-z.
Kauppila, A., and L. Rönnberg. “Naproxen Sodium in Dysmenorrhea Secondary to Endometriosis.” Obstetrics and Gynecology 65, no. 3 (March 1985): 379–83.
Lindeman, Tracey. Bleed: Destroying Myths and Misogyny in Endometriosis Care. Toronto, Ontario: ECW Press, 2023.
Mira, Ticiana A.A., Mariana M. Buen, Murilo G. Borges, Daniela A. Yela, and Cristina L. Benetti‐Pinto. “Systematic Review and Meta‐analysis of Complementary Treatments for Women with Symptomatic Endometriosis.” International Journal of Gynecology & Obstetrics 143, no. 1 (October 2018): 2–9. https://doi.org/10.1002/ijgo.12576
This metastudy looked at acupuncture, exercise, electrotherapy, and yoga in the treatment of endometriosis symptoms. Every method was deemed relatively inconclusive if vaguely positive; only acupuncture showed an improvement better than placebo. More controlled studies desperately needed.
Rižner, Tea Lanišnik, and Trevor M. Penning. “Aldo-Keto Reductase 1C3—Assessment as a New Target for the Treatment of Endometriosis.” Pharmacological Research 152 (February 2020): 104446. https://doi.org/10.1016/j.phrs.2019.104446.
Schwertner, André, Claudia C. Conceição Dos Santos, Gislene Dalferth Costa, Alícia Deitos, Andressa De Souza, Izabel Cristina Custodio De Souza, Iraci L.S. Torres, João Sabino L. Da Cunha Filho, and Wolnei Caumo. “Efficacy of Melatonin in the Treatment of Endometriosis: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.” Pain 154, no. 6 (June 2013): 874–81. https://doi.org/10.1016/j.pain.2013.02.025.
Seear, Kate. The Makings of a Modern Epidemic: Endometriosis, Gender and Politics. First issued in paperback. London: Routledge, 2018.
Sharma, Indu, Lakhbir Kaur Dhaliwal, Subhash Chand Saha, Sonal Sangwan, and Veena Dhawan. “Role of 8-Iso-Prostaglandin F2α and 25-Hydroxycholesterol in the Pathophysiology of Endometriosis.” Fertility and Sterility 94, no. 1 (June 2010): 63–70. https://doi.org/10.1016/j.fertnstert.2009.01.141.
Sourial, Samer, Nicola Tempest, and Dharani K. Hapangama. “Theories on the Pathogenesis of Endometriosis.” International Journal of Reproductive Medicine 2014 (2014): 1–9. https://doi.org/10.1155/2014/179515
Thorough examination of the various theories on the development of endometriosis, outlining where research should be headed. Offers a clear explanation why the “retrograde menstruation” theory does not make sense as a cause for endometriosis. Figure 1 is a clear graphical representation of how various factors, including oxidative stress, immune and apoptosis dysfunction, genetics, amongst others, can interact to produce superficial or deeply penetrating endometriosis.
Techatraisak, Kitirat, Andon Hestiantoro, Ruey Soon, Maria Jesusa Banal-Silao, Mee-Ran Kim, Seok Ju Seong, Syarief Thaufik Hidayat, Ling Cai, SoYoung Shin, and Byung Seok Lee. “Impact of Long-Term Dienogest Therapy on Quality of Life in Asian Women with Endometriosis: The Prospective Non-Interventional Study ENVISIOeN.” Reproductive Sciences 29, no. 4 (April 2022): 1157–69. https://doi.org/10.1007/s43032-021-00787-w.
Tourny, Claire, Amira Zouita, Samira El Kababi, Léa Feuillet, Ayoub Saeidi, Ismail Laher, Katja Weiss, Beat Knechtle, and Hassane Zouhal. “Endometriosis and Physical Activity: A Narrative Review.” International Journal of Gynecology & Obstetrics 163, no. 3 (December 2023): 747–56. https://doi.org/10.1002/ijgo.14898.
Ulukus, M., and A. Arici. “Immunology of Endometriosis.” Minerva Ginecologica 57, no. 3 (June 2005): 237–48.
Vitale, Salvatore Giovanni, Stella Capriglione, Isabel Peterlunger, Valentina Lucia La Rosa, Amerigo Vitagliano, Marco Noventa, Gaetano Valenti, et al. “The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner.” Oxidative Medicine and Cellular Longevity 2018 (2018): 1–14. https://doi.org/10.1155/2018/7924021.
The links between hypermobility, Ehlers-Danlos and endometriosis seem elusive, but could have an underlying genetic deficiency in vitamin B9 (folate) that affects connective tissue and eventually causes myriad seemingly unrelated symptoms including joint pain, chronic fatigue, thin tooth enamel, digestive trouble and migraines, endometriosis and uterine fibroids. While this article only briefly mentions endometriosis, folate does indirectly and directly produces antioxidant effects, which fits the big picture that oxidative stress is an underlying mechanism in endometriosis etiology. Archived article on archive.ph